محمد شاهپری

The purpose of this dissertation is to examine and compare the overall survival of patients with metastatic colorectal cancer treated with two bevacizumab drugs: a foreign and an Iranian version. Colorectal cancer is one of the most prevalent cancers worldwide, and its metastasis to other parts of the body poses significant challenges for patient treatment and management. In this study, survival analysis methods and Kaplan-Meier curves are employed to evaluate the impact of these two drugs on patient survival. In this research, clinical data from colorectal cancer patients treated with foreign and Iranian bevacizumab were collected and analyzed. Information on patients' age, gender, disease stage, and treatment start date was meticulously recorded and examined. Kaplan-Meier curves were used to compare the overall survival of patients treated with each drug. Furthermore, appropriate statistical methods, such as the log-rank test and hazard ratio models, were utilized for data analysis to investigate significant differences between the two drug groups. The results of this study can contribute to a better understanding of the therapeutic effects of different bevacizumab drugs and provide more optimal treatment strategies for colorectal cancer patients. Additionally, this research enables physicians and researchers to make better decisions regarding drug selection for their patients, ultimately helping to improve patients' quality of life. In conclusion, this dissertation emphasizes the importance of using survival analysis methods in clinical research and its impact on improving the quality of cancer patient treatment. The findings of this research can serve as a basis for future studies in the field of colorectal cancer treatment and comparisons of other drugs, contributing to the development of new treatment protocols.